ABSTRACT
On February 27, 2020, Santa Clara County, California, identified its first case of coronavirus disease 2019 (COVID-19) associated with probable community transmission. During March 5-14, among patients with respiratory symptoms evaluated at one of four Santa Clara County urgent care centers serving as sentinel surveillance sites, 23% had positive test results for influenza. Among a subset of patients with negative test results for influenza, 11% had positive test results for COVID-19. COVID-19 cases identified through this sentinel surveillance system helped confirm community transmission in the county. Local health departments can use sentinel surveillance to understand the level of community transmission of COVID-19 and to better guide the selection and implementation of community mitigation measures.